SBRI Stem-cell and Brain Research Institute - France (Lyon)

SBRI Team
:
Chronobiology and affective disorders

Major depression is the leading cause of disability worldwide and current treatments are limited in terms of efficacy, delay of action and undesirable side effects. Light plays a critical role, directly and through the circadian system on clock function, sleep regulation, and cognitive and emotional brain responses. Chronobiological mechanisms are considered to play a significant role in affective disorders and recent data point recent advances have confirmed the use of light exposure strategies in novel treatments for affective disorders. Our team is dedicated to study the control mechanisms of chronobiological rhythms and fast and effective antidepressant responses. Our strategy has two main axes:

  • Non-visual responses to light: mechanisms and applications. Our objective is to understand the basic mechanisms of non-visual photoreception and the effects of light on circadian rhythms, physiology and gene regulation in normal and pathological states. our studies address the cellular and molecular mechanisms underscoring circadian regulation, via an in-depth analysis of the photoreceptive pathways and genetic signaling of the retinal network. We employ innovative modeling techniques to derive the contributions of different photoreceptors using different response assays. The large scale circadian regulation of the non-human primate transcriptome and the effects of light stimulation on major brain structures and body organs are assayed
  • Early-onset antidepressant strategies: neurobiological mechanisms. In vivo evaluation of the impact of fast acting antidepressants on mood and cognition as well as on cerebral networks and plasticity will provide a better understanding of the neurobiological mechanisms underlying the antidepressant responsiveness in refractory major depression. In addition, to further improve antidepressants effectiveness, we will determine the potentiating effects of light exposure on the antidepressant response.

The results arising from the basic research of our program should be translated to potential clinical applications and be of important interest for public health.

SBRI Team
: Chronobiology and affective disorders

Members list

Howard Cooper
Team Leader / DRE

Howard Cooper
Team Leader / DRE

Nasser Haddjeri
Team Leader / CR1

Nasser Haddjeri
Team Leader / CR1

Ouria Dkhissi-Benyahya
CR1

Hélène Scarna
IR

Christine Coutanson
AI

Renaud Rovera
TR

Hugo Calligaro
PhD Student

Sarah Delcourte
PhD Student

Chaimaa Kinane
PhD Student

Selected Publications

Yearsort descending Reference Title Authors Journal PUB MED PDF