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SBRI member :

Pierre Misery
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IE

Research interests

I am working on the cortico-cortical connectivity of the macaque. We use retrograde tracers to examine topography of interareal connectivity. To do this, we inject tracers in the brain of macaque using MRI guided technology (Brain Sight). We carry out histological processing on the brain so as to accurately allocate labelled neurons to particular cortical areas. An important aspect of the analysis of the material is the recording of the XY coordinates of very large numbers of neurons using a digitalised image system running on Explora Nova software (Mercator). With Explora Nova we are currently developing two major approaches to improving our work. Firstly, a fully automatic dedicated microscopy station able to chart fluorescent cells in individual cortical layers and areas. This will make it possible to reduce processing time by up to 80% and will make it possible to greatly extend the scope of our enquiry. Secondly, the ability to construct 3 and 2D reconstructions of cortical labelling. This will make it possible to obtain accurate data on individual neuron pathway length, important for our on going modelling of the networks of the cerebral cortex.

3B
Building the cerebral cortex: Connectomics
histology-microscopy

Histology and microscopy

connectomics_ok

Connectomics

YearAuthorsTitleJournalPubMedPDF
2022Wianny F, Dzahini K, Fifel K, Wilson CRE, Bernat A, Dolmazon V, Misery P, Lamy C, Giroud P, Cooper HM, Knoblauch K, Procyk E, Kennedy H, Savatier P, Dehay C, Vezoli JInduced Cognitive Impairments Reversed by Grafts of Neural Precursors: A Longitudinal Study in a Macaque Model of Parkinson's DiseaseAdv Sci (Weinh)
2014Markov NT, Ercsey-Ravasz MM, Ribeiro Gomes AR, Lamy C, Magrou L, Vezoli J, Misery P, Falchier A, Quilodran R, Gariel MA, Sallet J, Gamanut R, Huissoud C, Clavagnier S, Giroud P, Sappey-Marinier D, Barone P, Dehay C, Toroczkai Z, Knoblauch K, Van Essen DC, Kennedy HA weighted and directed interareal connectivity matrix for macaque cerebral cortexCereb Cortex
2014Markov NT, Vezoli J, Chameau P, Falchier A, Quilodran R, Huissoud C, Lamy C, Misery P, Giroud P, Ullman S, Barone P, Dehay C, Knoblauch K, Kennedy HAnatomy of hierarchy: feedforward and feedback pathways in macaque visual cortexJ Comp Neurol
2013Markov NT, Ercsey-Ravasz M, Lamy C, Ribeiro Gomes AR, Magrou L, Misery P, Giroud P, Barone P, Dehay C, Toroczkai Z, Knoblauch K, Van Essen DC, Kennedy HThe role of long-range connections on the specificity of the macaque interareal cortical networkProc Natl Acad Sci U S A
2011Markov NT, Misery P, Falchier A, Lamy C, Vezoli J, Quilodran R, Gariel MA, Giroud P, Ercsey-Ravasz M, Pilaz LJ, Huissoud C, Barone P, Dehay C, Toroczkai Z, Van Essen DC, Kennedy H, Knoblauch KWeight consistency specifies regularities of macaque cortical networksCereb Cortex
2005Mithieux G, Misery P, Magnan C, Pillot B, Gautier-Stein A, Bernard C, Rajas F, Zitoun CPortal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet proteinCell Metab