Ouria Dkhissi-Benyahya Team Leader / CRCN
Chronobiology and Affective Disorders
Major depression is the leading cause of disability worldwide and current treatments are limited in terms of efficacy, delay of action and undesirable side effects. Light plays a critical role, directly and through the circadian system on clock function, sleep regulation, and cognitive and emotional brain responses. Chronobiological mechanisms are considered to play a significant role in affective disorders and recent data point recent advances have confirmed the use of light exposure strategies in novel treatments for affective disorders. Our team is dedicated to study the control mechanisms of chronobiological rhythms and fast and effective antidepressant responses. Our strategy has two main axes:
The results arising from the basic research of our program should be translated to potential clinical applications and be of important interest for public health.
Year | Reference |
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Authors | Journal | PUB MED | ||
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2020 | 26:106-116 | A standardized method to assess the endogenous activity and the light-response of the retinal clock in mammals | H Calligaro, C Kinane, M Bennis, C Coutanson, O Dkhissi-Benyahya | Mol Vis | - | ||
2021 | 22(2):E937 | Learned Immobility Produces Enduring Impairment of the HPA Axis Reactivity in Mice without Replicating the Broad Spectrum of Depressive-Like Phenotype | Sébastien Bullich, Sarah Delcourte, Nasser Haddjeri, Bruno P Guiard | Int J Mol Sci | - | ||
2019 | 6(3):ENEURO.0021-19.2019. doi: 10.1523/ENEURO.0021-19.2019 | Serotonin Neuronal Function from the Bed to the Bench: Is This Really a Mirrored Way? | Adeline Etievant, Thorsten Lau, Guillaume Lucas, Nasser Haddjeri | eNeuro | - | ||
2020 | pp 1-19 | Antidepressants: Molecular Aspects of SSRIs | Etievant A, Haddjeri N, Lau T | NeuroPsychopharmacotherapy | - | ||
2015 | 2(8):898-908 | Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation | Etiévant A, Oosterhof C, Bétry C, Abrial E, Novo-Perez M, Rovera R, Scarna H, Devader C, Mazella J, Wegener G, Sánchez C, Dkhissi-Benyahya O, Gronfier C, Coizet V, Beaulieu JM, Blier P, Lucas G, Haddjeri N | EBioMedicine | - | ||
2016 | 80(6):e43-e44 | Deep Brain Stimulation for Depression: Is It a Gray or White "Matter"? | Etiévant A, Lucas G, Haddjeri N | Biol Psychiatry | - | ||
2018 | 359(6381) | Diurnal transcriptome atlas of a primate across major neural and peripheral tissues | Ludovic S. Mure, Hiep D. Le, Giorgia Benegiamo, Max W. Chang, Luis Rios, Ngalla Jillani, Maina Ngotho, Thomas Kariuki, Ouria Dkhissi-Benyahya, Howard M. Cooper, Satchidananda Panda | Science | - | ||
2020 | 229(1):e13440. doi: 10.1111/apha.13440 | Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs | Benjamin Portal, Sarah Delcourte, Renaud Rovera, Camille Lejards, Sebastien Bullich, Cécile E Malnou, Nasser Haddjeri, Nicole Déglon, Bruno P Guiard | Acta Physiol (Oxf) | - | ||
2018 | 23(3):587-596 | Inducing a long-term potentiation in the dentate gyrus is sufficient to produce rapid antidepressant-like effects | Kanzari A, Bourcier-Lucas C, Freyssin A, Abrous DN, Haddjeri N, Lucas G | Mol Psychiatry | - | ||
2007 | 53(5):677-87 | Modeling the role of mid-wavelength cones in circadian responses to light | Dkhissi-Benyahya O, Gronfier C, De Vanssay W, Flamant F, Cooper HM | Neuron | |||