We have established major differences in the nature and timing of the ontogenetic processes that characterize primate corticogenesis and were the first to identify a human and non-human primate-specific germinal zone: the Outer Sub Ventricular Zone (OSVZ) (Smart et al., 2002) . We have shown that the primate OSVZ includes a high diversity of progenitors including five morphotypes, each characterized by distinct proliferative behaviors. State transition analysis of a large database of lineage trees unexpectedly revealed frequent bidirectional transitions between progenitor types, not observed in other mammalian species (Betizeau et al., Neuron, 2013; Pfeiffer et al., J Comp Neurol, 2016).
We have discovered that primate-specific miRNA signatures uniquely distinguish VZ and OSVZ. Many of these primate-specific miRNAs target cell-cycle genes, indicating that each germinal zone has evolved its own cell-cycle regulation scheme. This suggests the evolution of a complex regulatory control system that may have contributed to the emergence of novel progenitor types interacting through complex lineages. (Arcila et al. Neuron, 2014; Dehay et al., Neuron, 2015)
One of major contributions include discovery of the role of cell-cycle regulation in establishing cortical architecture and cell lineage evolution, via control of cortical progenitor pool amplification and on mode of division (Pilaz et al., PNAS, 2009; Lukaszewicz et al., Neuron, 2005; Dehay and Kennedy, Nat Rev Neurosci, 2007). We have shown that a conserved mechanism, the asymmetrical spindle morphology (SSA) , known to be a core component of ACD in invertebrates is implicated in mammalian corticogenesis where it regulates cell-cycle exit and asymmetric division in apical progenitors of the VZ (Delaunay et al., 2014, Cell Reports, 2014; Delaunay et al., Curr Opin Neurobiol, 2017).
|2020||Magrou L, Barone P, Markov NT, Scheeren G, Killackey HP, Giroud P, Berland M, Knoblauch K, Dehay C*, Kennedy H*, *co-senior authors||Unique Features of Subcortical Circuits in a Macaque Model of Congenital Blindness||Cereb Cortex|
|2020||Ribeiro Gomes AR, Olivier E, Killackey HP, Giroud P, Berland M, Knoblauch K, Dehay C*, Kennedy H*, *co-senior authors, F1000 recommandation||Refinement of the Primate Corticospinal Pathway During Prenatal Development.||Cereb Cortex|
|2020||Luanda Lins, Florence Wianny, Colette Dehay, Jacques Jestin, Watson Loh||Adhesive Sponge Based on Supramolecular Dimers Interactions as Scaffolds for Neural Stem Cells||Biomacromolecules|
|2019||Arai Y, Cwetsch AW, Coppola E, Cipriani S, Nishihara H, Kanki H, Saillour Y, Freret-Hodara B, Dutriaux A, Okada N, Okano H, Dehay C, Nardelli J, Gressens P, Shimogori T, D'Onofrio G, Pierani A||Evolutionary Gain of Dbx1 Expression Drives Subplate Identity in the Cerebral Cortex.||Cell Rep|
|2019||Fousse J, Gautier E, Patti D, Dehay C||Developmental changes in interkinetic nuclear migration dynamics with respect to cell-cycle progression in the mouse cerebral cortex ventricular zone.||J Comp Neurol|
|2018||Borello U, Kennedy H, Dehay C||The logistics of afferent cortical specification in mice and men||Semin Cell Dev Biol|
|2018||Magrou L, Barone P, Markov NT, Killackey HP, Giroud P, Berland M, Knoblauch K, Dehay C*, Kennedy H*, *co-senior authors||How Areal Specification Shapes the Local and Interareal Circuits in a Macaque Model of Congenital Blindness||Cereb Cortex|
|2018||Wianny F, Kennedy H, Dehay C||Bridging the Gap between Mechanics and Genetics in Cortical Folding: ECM as a Major Driving Force||Neuron|
|2018||Borello U, Berarducci B, Delahaye E, Price DJ, Dehay C||SP8 Transcriptional Regulation of Cyclin D1 During Mouse Early Corticogenesis.||Front Neurosci|
|2017||Delaunay D, Kawaguchi A, Dehay C, Matsuzaki F||Division modes and physical asymmetry in cerebral cortex progenitors||Curr Opin Neurobiol|