Alumni Team : "Chronobiology and affective disorders"
The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease. Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information by retinal photoreceptors (rods, cones, melanopsin ganglion cells) are studied using in vivo electrophysiological recording techniques in anaesthetised and awake, freely moving animals. The effects of light (intensity, duration, spectrum) on SCN neuronal activity and on clock gene expression are also assayed using quantitative RT-PCR and microarray analysis. In order to understand the consequences of chronobiological disorders, another line of research involves investigation of the mechanisms of synchronisation of central and peripheral oscillators, including the expression of clock genes and rhythmically expressed clock controlled genes in the brain and in different body tissues. Pathological models studied include ocular diseases and Parkinson's disease in rodents and aging in a prosimian primate. In humans, circadian photoreception and entrainment of the circadian timing system as well as chronobiological disorders related to ocular pathologies, aging and neurodegenerative diseases are studied in the framework of a European integrated project EUClock in our clinically based Platform for Research on Human Chronobiology. In order to bridge the gap between cellular-molecular studies in rodent models and clinical studies in humans, the non-human primate is used to study the circadian timing system and sleep wake cycle and, in the framework of the laboratory transverse project, the chronobiological consequences of Parkinson's Disease.
|1987||324(6096):457-9||A common mammalian plan of accessory optic system organization revealed in all primates||Cooper HM, Magnin M||Nature|
|2000||275(49):38674-9||A fully functional rod visual pigment in a blind mammal. A case for adaptive functional reorganization?||Janssen JW, Bovee-Geurts PH, Peeters ZP, Bowmaker JK, Cooper HM, David-Gray ZK, Nevo E, DeGrip WJ||J Biol Chem|
|1986||49(850-854)||A microcomputer data acquisition-telemetry system: a study of activity in the bat||Cooper HM||Journal of Wildlife management||-|
|1994||51(2):189-95||A new surgical approach to the ram suprachiasmatic nuclei||Locatelli A, Caldani M, Tessonneaud A, Cooper HM, Viguier-Martinez MC||J Neurosci Methods||-|
|1987||259(4):467-82||Accessory optic system of an anthropoid primate, the gibbon (Hylobates concolor): evidence of a direct retinal input to the medial terminal nucleus||Cooper HM, Magnin M||J Comp Neurol||-|
|2014||9(1):e85837||Aging of non-visual spectral sensitivity to light in humans: compensatory mechanisms?||Najjar RP, Chiquet C, Teikari P, Cornut PL, Claustrat B, Denis P, Cooper HM, Gronfier C||PLoS One|
|2014||9(1):e86240||Alteration of daily and circadian rhythms following dopamine depletion in MPTP treated non-human primates||Fifel K, Vezoli J, Dzahini K, Claustrat B, Leviel V, Kennedy H, Procyk E, Dkhissi-Benyahya O, Gronfier C, Cooper HM||PLoS One||-|
|2012||211(2):227-36||An inexpensive Arduino-based LED stimulator system for vision research||Teikari P, Najjar RP, Malkki H, Knoblauch K, Dumortier D, Gronfier C, Cooper HM||J Neurosci Methods|
|2002||17(2):121-36||Analysis of immunohistochemical label of Fos protein in the suprachiasmatic nucleus: comparison of different methods of quantification||Rieux C, Carney R, Lupi D, Dkhissi-Benyahya O, Jansen K, Chounlamountri N, Foster RG, Cooper HM||J Biol Rhythms|
|2001||105(2):403-12||Artificially accelerated aging by shortened photoperiod alters early gene expression (Fos) in the suprachiasmatic nucleus and sulfatoxymelatonin excretion in a small primate, Microcebus murinus||Aujard F, Dkhissi-Benyahya O, Fournier I, Claustrat B, Schilling A, Cooper HM, Perret M||Neuroscience|