Alumni Team : "Chronobiology and affective disorders"
The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease. Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information by retinal photoreceptors (rods, cones, melanopsin ganglion cells) are studied using in vivo electrophysiological recording techniques in anaesthetised and awake, freely moving animals. The effects of light (intensity, duration, spectrum) on SCN neuronal activity and on clock gene expression are also assayed using quantitative RT-PCR and microarray analysis. In order to understand the consequences of chronobiological disorders, another line of research involves investigation of the mechanisms of synchronisation of central and peripheral oscillators, including the expression of clock genes and rhythmically expressed clock controlled genes in the brain and in different body tissues. Pathological models studied include ocular diseases and Parkinson's disease in rodents and aging in a prosimian primate. In humans, circadian photoreception and entrainment of the circadian timing system as well as chronobiological disorders related to ocular pathologies, aging and neurodegenerative diseases are studied in the framework of a European integrated project EUClock in our clinically based Platform for Research on Human Chronobiology. In order to bridge the gap between cellular-molecular studies in rodent models and clinical studies in humans, the non-human primate is used to study the circadian timing system and sleep wake cycle and, in the framework of the laboratory transverse project, the chronobiological consequences of Parkinson's Disease.
|2012||211(2):227-36||An inexpensive Arduino-based LED stimulator system for vision research||Teikari P, Najjar RP, Malkki H, Knoblauch K, Dumortier D, Gronfier C, Cooper HM||J Neurosci Methods|
|2007||22(5):411-24||Melanopsin-dependent nonvisual responses: evidence for photopigment bistability in vivo||Mure LS, Rieux C, Hattar S, Cooper HM||J Biol Rhythms|
|2008||23(1):37-48||Photic sensitivity ranges of hamster pupillary and circadian phase responses do not overlap||Hut RA, Oklejewicz M, Rieux C, Cooper HM||J Biol Rhythms|
|2008||23(5):392-3||Expected and unexpected properties of melanopsin signaling||Cooper HM, Mure LS||J Biol Rhythms|
|2001||24(6): 659-71||The eye and circadian rhythms||Chiquet C, Dkhissi-Benyahya O, Cooper HM, Claustrat B, Denis P||J Fr Ophtalmol||-|
|1986||249(1):28-47||The accessory optic system in a prosimian primate (Microcebus murinus): evidence for a direct retinal projection to the medial terminal nucleus||Cooper HM||J Comp Neurol||-|
|1987||259(4):467-82||Accessory optic system of an anthropoid primate, the gibbon (Hylobates concolor): evidence of a direct retinal input to the medial terminal nucleus||Cooper HM, Magnin M||J Comp Neurol||-|
|2012||27(3):257-64||Does pupil constriction under blue and green monochromatic light exposure change with age?||Daneault V, Vandewalle G, Hébert M, Teikari P, Mure LS, Doyon J, Gronfier C, Cooper HM, Dumont M, Carrier J||J Biol Rhythms||-|
|2007||27(36):9623-31||Responses of suprachiasmatic nucleus neurons to light and dark adaptation: relative contributions of melanopsin and rod-cone inputs||Drouyer E, Rieux C, Hut RA, Cooper HM||J Neurosci|
|2010||27(4):768-81||Cones are required for normal temporal responses to light of phase shifts and clock gene expression||Dollet A, Albrecht U, Cooper HM, Dkhissi-Benyahya O||Chronobiol Int|