Alumni Team : "Chronobiology and affective disorders"
The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease. Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information by retinal photoreceptors (rods, cones, melanopsin ganglion cells) are studied using in vivo electrophysiological recording techniques in anaesthetised and awake, freely moving animals. The effects of light (intensity, duration, spectrum) on SCN neuronal activity and on clock gene expression are also assayed using quantitative RT-PCR and microarray analysis. In order to understand the consequences of chronobiological disorders, another line of research involves investigation of the mechanisms of synchronisation of central and peripheral oscillators, including the expression of clock genes and rhythmically expressed clock controlled genes in the brain and in different body tissues. Pathological models studied include ocular diseases and Parkinson's disease in rodents and aging in a prosimian primate. In humans, circadian photoreception and entrainment of the circadian timing system as well as chronobiological disorders related to ocular pathologies, aging and neurodegenerative diseases are studied in the framework of a European integrated project EUClock in our clinically based Platform for Research on Human Chronobiology. In order to bridge the gap between cellular-molecular studies in rodent models and clinical studies in humans, the non-human primate is used to study the circadian timing system and sleep wake cycle and, in the framework of the laboratory transverse project, the chronobiological consequences of Parkinson's Disease.
|1978||1: 941-9||Learning set in prosimians||Cooper HM||Recent advances in Primatology||-|
|1979||187(1):145-67||Thalamic projections to area 17 in a prosimian primate, Microcebus murinus||Cooper HM, Kennedy H, Magnin M, Vital-Durand F||J Comp Neurol||-|
|1980||VII 323-9||Radioautography 2-deoxyglucose patterns elicited by female odors in the male rat olfactory bulb||Cooper HM||Olfaction and taste||-|
|1985||35(4):509-16||Influence of female odors on lateral hypothalamus in the male rat. Semiquantitative deoxyglucose analysis||Orsini JC, Jourdan F, Cooper HM, Monmaur P||Physiol Behav||-|
|1986||249(1):28-47||The accessory optic system in a prosimian primate (Microcebus murinus): evidence for a direct retinal projection to the medial terminal nucleus||Cooper HM||J Comp Neurol||-|
|1986||49(850-854)||A microcomputer data acquisition-telemetry system: a study of activity in the bat||Cooper HM||Journal of Wildlife management||-|
|1986||132: 145-57||Frugivorie et transport de graines de cercopria par les chauve-souris de Guyane||Charles-Dominique P, Cooper HM||Mémoire du M.N.H.M (Paris)||-|
|1986||132: 131-43||Signification de la coloration des fruits en fonction de la vision des vertérébrés consommateurs||Cooper HM, Charles-Dominique P, Vienot P||Mémoires du M.N H.N. (Paris)||-|
|1987||324(6096):457-9||A common mammalian plan of accessory optic system organization revealed in all primates||Cooper HM, Magnin M||Nature|
|1987||259(4):467-82||Accessory optic system of an anthropoid primate, the gibbon (Hylobates concolor): evidence of a direct retinal input to the medial terminal nucleus||Cooper HM, Magnin M||J Comp Neurol||-|