Alumni Team : "Chronobiology and affective disorders"
The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease. Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information by retinal photoreceptors (rods, cones, melanopsin ganglion cells) are studied using in vivo electrophysiological recording techniques in anaesthetised and awake, freely moving animals. The effects of light (intensity, duration, spectrum) on SCN neuronal activity and on clock gene expression are also assayed using quantitative RT-PCR and microarray analysis. In order to understand the consequences of chronobiological disorders, another line of research involves investigation of the mechanisms of synchronisation of central and peripheral oscillators, including the expression of clock genes and rhythmically expressed clock controlled genes in the brain and in different body tissues. Pathological models studied include ocular diseases and Parkinson's disease in rodents and aging in a prosimian primate. In humans, circadian photoreception and entrainment of the circadian timing system as well as chronobiological disorders related to ocular pathologies, aging and neurodegenerative diseases are studied in the framework of a European integrated project EUClock in our clinically based Platform for Research on Human Chronobiology. In order to bridge the gap between cellular-molecular studies in rodent models and clinical studies in humans, the non-human primate is used to study the circadian timing system and sleep wake cycle and, in the framework of the laboratory transverse project, the chronobiological consequences of Parkinson's Disease.
|2002||17(2):121-36||Analysis of immunohistochemical label of Fos protein in the suprachiasmatic nucleus: comparison of different methods of quantification||Rieux C, Carney R, Lupi D, Dkhissi-Benyahya O, Jansen K, Chounlamountri N, Foster RG, Cooper HM||J Biol Rhythms|
|2002||115(4):1323-33||Characterization of calbindin-positive cones in primates||Chiquet C, Dkhissi-Benyahya O, Chounlamountri N, Szel A, Degrip WJ, Cooper HM||Neuroscience|
|2003||967(1-2):48-62||Organization of the circadian system in the subterranean mole rat, Cryptomys hottentotus (Bathyergidae)||Negroni J, Bennett NC, Cooper HM||Brain Res|
|2003||18(6):481-90||Circadian rhythms of locomotor activity in solitary and social species of African mole-rats (family: Bathyergidae)||Oosthuizen MK, Cooper HM, Bennett NC||J Biol Rhythms|
|2003||965(1-2):1-8||Increased masking response to light after ablation of the visual cortex in mice||Redlin U, Cooper HM, Mrosovsky N||Brain Res|
|2003||464(2):159-71||Differential patterns of glial fibrillary acidic protein-immunolabeling in the brain of adult lizards||Ahboucha S, Laalaoui A, Didier-Bazes M, Montange M, Cooper HM, Gamrani H||J Comp Neurol|
|2003||18(1):71-9||Inferior retinal light exposure is more effective than superior retinal exposure in suppressing melatonin in humans||Glickman G, Hanifin JP, Rollag MD, Wang J, Cooper H, Brainard GC||J Biol Rhythms|
|2005||133(2):555-60||Fos expression in the suprachiasmatic nucleus in response to light stimulation in a solitary and social species of African mole-rat (family Bathyergidae)||Oosthuizen MK, Bennett NC, Cooper HM||Neuroscience|
|2005||68(3):185-94||Calcium-binding protein distribution in the retina of strepsirhine and haplorhine primates||Chiquet C, Dkhissi-Benyahya O, Cooper HM||Brain Res Bull|
|2005||84(2):181-91||Circadian rhythms of locomotor activity in the subterranean Mashona mole rat, Cryptomys darlingi||Vasicek CA, Oosthuizen MK, Cooper HM, Bennett NC||Physiol Behav|