Alumni Team : "Chronobiology and affective disorders"
The research aims of Neurobiological Rhythms and Sleep are focused on the molecular, cellular and behavioral mechanisms of the circadian timing system and the consequences of aging and neurodegenerative disease. Our approaches strive to understand the mechanisms of synchronization of circadian rhythms by lignt, the molecular and physiological mechanisms of the endogenous circadian oscillators, and the regulation of output behavioral and physiological rhythms. The coding of photic information by retinal photoreceptors (rods, cones, melanopsin ganglion cells) are studied using in vivo electrophysiological recording techniques in anaesthetised and awake, freely moving animals. The effects of light (intensity, duration, spectrum) on SCN neuronal activity and on clock gene expression are also assayed using quantitative RT-PCR and microarray analysis. In order to understand the consequences of chronobiological disorders, another line of research involves investigation of the mechanisms of synchronisation of central and peripheral oscillators, including the expression of clock genes and rhythmically expressed clock controlled genes in the brain and in different body tissues. Pathological models studied include ocular diseases and Parkinson's disease in rodents and aging in a prosimian primate. In humans, circadian photoreception and entrainment of the circadian timing system as well as chronobiological disorders related to ocular pathologies, aging and neurodegenerative diseases are studied in the framework of a European integrated project EUClock in our clinically based Platform for Research on Human Chronobiology. In order to bridge the gap between cellular-molecular studies in rodent models and clinical studies in humans, the non-human primate is used to study the circadian timing system and sleep wake cycle and, in the framework of the laboratory transverse project, the chronobiological consequences of Parkinson's Disease.
|2006||47(4):1636-41||Immunohistochemical evidence of a melanopsin cone in human retina||Dkhissi-Benyahya O, Rieux C, Hut RA, Cooper HM||Invest Ophthalmol Vis Sci|
|2014||102 Pt 2:249-61||Increased DAT binding in the early stage of the dopaminergic lesion: a longitudinal [11C]PE2I binding study in the MPTP-monkey||Vezoli J, Dzahini K, Costes N, Wilson CR, Fifel K, Cooper HM, Kennedy H, Procyk E||Neuroimage||-|
|2003||965(1-2):1-8||Increased masking response to light after ablation of the visual cortex in mice||Redlin U, Cooper HM, Mrosovsky N||Brain Res|
|2003||18(1):71-9||Inferior retinal light exposure is more effective than superior retinal exposure in suppressing melatonin in humans||Glickman G, Hanifin JP, Rollag MD, Wang J, Cooper H, Brainard GC||J Biol Rhythms|
|1985||35(4):509-16||Influence of female odors on lateral hypothalamus in the male rat. Semiquantitative deoxyglucose analysis||Orsini JC, Jourdan F, Cooper HM, Monmaur P||Physiol Behav||-|
|1999||117(6):848||Is the study of blind patients useful for understanding light perception?||Chiquet C, Dkhissi-Benyahya O, Cooper HM||Arch Ophthalmol||-|
|1998||805(1-2):213-9||Is there a geniculohypothalamic tract in primates? A comparative immunohistochemical study in the circadian system of strepsirhine and haplorhine species||Chevassus-au-Louis N, Cooper HM||Brain Res|
|2013||30(6):741-55||Lack of long-term changes in circadian, locomotor, and cognitive functions in acute and chronic MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse models of Parkinson's disease||Fifel K, Dkhissi-Benyahya O, Cooper HM||Chronobiol Int||-|
|1978||1: 941-9||Learning set in prosimians||Cooper HM||Recent advances in Primatology||-|
|2006||70(4-6):270-7||Light-induced Fos expression in the suprachiasmatic nucleus of the four-striped field mouse, Rhabdomys pumilio: A southern African diurnal rodent||Schumann DM, Cooper HM, Hofmeyr MD, Bennett NC||Brain Res Bull|