Using patient-derived induced pluripotent stem cell models to define the role of pathogenic DNMT3A mutations in neurodevelopmental disorders
Thursday 27th march, 13:00 / SBRI conference room
Serge Mc Graw (Developmental Epigenetics and Neurodevelopment Lab University of Montreal, Canada)
Dr. Serge McGraw principal research interests are focused on the detrimental developmental outcomes caused by epigenetic instabilities arising from alterations in DNA methylation profiles during early embryogenesis. By combining patient-derived in vitro stem cell models, mouse embryonic stem cells, as well as in vivo mouse models, with multi-omics sequencing approaches, his laboratory aims at understanding how epigenetic dysregulation in early embryonic cells leads to gene expression errors driving the occurrence of developmental and neurodevelopmental disorders.
