We seek to understand how neural networks in the brain produce complex cognition. Specifically we take established knowledge about simple systems in the brain and understand how it can be applied to higher cognitive functions, often referred to as executive functions. These are functions that allow flexible behaviours that can be readily adapted in volatile environments. So for example neural firing rate, neural synchronization and oscillations are mechanisms by which the brain stores, transmits, and manipulates distributed information in simple perceptual functions. But how these mechanisms apply to higher cognitive functions it little understood.
We know that executive functions require appropriate interactions between large-scale neural networks, as well as modulation by monoaminergic systems. Our research targets the mechanisms of these processes, in particular in primate species. Executive functions, and their neural bases, have unique characteristics in primate species, and in humans in particular.
Our current projects aim at exploring how cognitive processes are specified by neural activity and dynamical interactions between frontal cortical areas, how neuromodulation contributes, and how network interactions change during adaptive behaviours. The frontal cortex has particularly evolved across mammals and in primates in particular. Our research also seeks to identify anatomical and functional principles of the frontal cortex that are conserved or that differ between primate species. Finally, we study the neural basis of the acquisition of these executive processes. We want to understand how the way in which executive functions are learned and acquired in the brain influences later cognition, with implications in a number of fields.
To address these questions we use multiple techniques (anatomy of connectivity, multiple-microelectrodes, ECoG, EEG, fMRI) to describe the anatomy and function of networks involved in higher cognitive functions in primates. We therefore employ a multi-level and comparative approach to studying cognitive processes. We build upon methods and techniques established at SBRI, as well as developing new theoretical, anatomical and technological approaches in collaboration with colleagues all over the world.
Year | Authors | Title | Journal | PubMed | |
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2025 | Langford ZD, Wilson CRE | Simulations reveal that beta burst detection may inappropriately characterize the beta band | J Neurophysiol | ||
2025 | Caffaratti H, Slater B, Shaheen N, Rhone A, Calmus R, Kritikos M, Kumar S, Dlouhy B, Oya H, Griffiths T, Boes AD, Trapp N, Kaiser M, Sallet J, Banks MI, Howard MA, Zanaty M, Petkov CI. | Temporal Dynamics of Offline Transcranial Ultrasound Stimulation | Current Research in Neurobiology | ||
2025 | Di Geronimo C, Destexhe A, Di Volo M | Biologically realistic mean field model of spiking neural networks with fast and slow inhibitory synapses | J Comput Neurosci. | ||
2024 | Caffaratti H, Slater B, Shaheen N, Rhone A, Calmus R, Kritikos M, Kumar S, Dlouhy B, Oya H, Griffiths T, Boes AD, Trapp N, Kaiser M, Sallet J, Banks MI, Howard MA 3rd, Zanaty M, Petkov CI | Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and a Community | eLife | ||
2024 | Atkinson-Clement C, Alkhawashki M, Ross J, Gatica M, Zhang C, Sallet J, Kaiser M | Dynamical and individualised approach of transcranial ultrasound neuromodulation effects in non-human primates | Sci Rep | ||
2024 | Gatica M, Atkinson-Clement C, Mediano PAM, Alkhawashki M, Ross J, Sallet J, Kaiser M | Transcranial ultrasound stimulation effect in the redundant and synergistic networks consistent across macaques | Netw Neurosci | ||
2024 | DeCasien AR, Chiou KL, Testard C, Mercer A, Negrón-Del Valle JE, Bauman Surratt SE, González O, Stock MK, Ruiz-Lambides AV, Martínez MI; Cayo Biobank Research Unit; Antón SC, Walker CS, Sallet J, Wilson MA, Brent LJN, Montague MJ, Sherwood CC, Platt ML, Higham JP, Snyder-Mackler N | Evolutionary and biomedical implications of sex differences in the primate brain transcriptome. | Cell Genom | ||
2024 | Mahmoodi A, Harbison C, Bongioanni A, Emberton A, Roumazeilles L, Sallet J, Khalighinejad N, Rushworth MFS | A frontopolar-temporal circuit determines the impact of social information in macaque decision making | Neuron | ||
2024 | Bryant KL, Manger PR, Bertelsen MF, Khrapitchev AA, Sallet J, Benn RA, Mars RB | A map of white matter tracts in a lesser ape, the lar gibbon | Brain Struct Funct | ||
2024 | Goldobin DS, di Volo M, Torcini A | Discrete synaptic events induce global oscillations in balanced neural networks | Phys Rev Lett |