We explore the mechanisms of self-renewal and pluripotency using embryonic stem cells from several mammalian sepcies. In particular, we explore ground state pluripotency in the rabbit and primate pre-implantation embryos.
Our goal is to create rabbit and macaque ES cells capable of colonizing the developing embryo, suitable for the generation of chimaeras.
Another aspect of our work focuses on the regulation of the cell cycle, which shows unusual characteristics in pluripotent stem cells.
| Year | Authors | Title | Journal | PubMed | |
|---|---|---|---|---|---|
| 2023 | Preeyanan Anwised, Ratree Moorawong, Worawalan Samruan, Sirilak Somredngan, Jittanun Srisutush, Chuti Laowtammathron, Irene Aksoy, Rangsun Parnpai, Pierre Savatier | An expedition in the jungle of pluripotent stem cells of non-human primates | Stem Cell Reports | ||
| 2022 | Wilhelm Bouchereau, Luc Jouneau, Catherine Archilla, Irène Aksoy, Anais Moulin, Nathalie Daniel, Nathalie Peynot, Sophie Calderari, Thierry Joly, Murielle Godet, Yan Jaszczyszyn, Marine Pratlong, Dany Severac, Pierre Savatier, Véronique Duranthon, Marielle Afanassieff, Nathalie Beaujean | Major transcriptomic, epigenetic and metabolic changes underlie the pluripotency continuum in rabbit preimplantation embryos | Development | ||
| 2022 | Wianny F, Dzahini K, Fifel K, Wilson CRE, Bernat A, Dolmazon V, Misery P, Lamy C, Giroud P, Cooper HM, Knoblauch K, Procyk E, Kennedy H, Savatier P, Dehay C, Vezoli J | Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: A Longitudinal Study in a Macaque Model of Parkinson's Disease | Adv Sci (Weinh) | ||
| 2022 | Fadlullah MZH, Neo WH, Lie-A-Ling M, Thambyrajah R, Patel R, Mevel R, Aksoy I, Do Khoa N, Savatier P, Fontenille L, Baker SM, Rattray M, Kouskoff V, Lacaud G | Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE | Blood | ||
| 2021 | Savatier P, Aksoy I | Interspecies systemic chimeras | Med Sci (Paris) | ||
| 2021 | Savatier P, David L, De Vos J, Yates F, Tajbakhsh S, Martinat C | Chimeric embryos and pseudo-embryos: An alternative to human embryos for research | Med Sci (Paris) | ||
| 2021 | Savatier P | Introduction of Mouse Embryonic Fibroblasts into Early Embryos Causes Reprogramming and (Con)fusion | Cells | ||
| 2021 | Aksoy I, Rognard C, Moulin A, Marcy G, Masfaraud E, Wianny F, Cortay V, Bellemin-Ménard A, Doerflinger N, Dirheimer M, Mayère C, Bourillot PY, Lynch C, Raineteau O, Joly T, Dehay C, Serrano M, Afanassieff M, Savatier P | Apoptosis, G1 Phase Stall, and Premature Differentiation Account for Low Chimeric Competence of Human and Rhesus Monkey Naive Pluripotent Stem Cells | Stem Cell Reports | ||
| 2020 | Lynch CJ, Bernad R, Martínez-Val A, Shahbazi MN, Nóbrega-Pereira S, Calvo I, Blanco-Aparicio C, Tarantino C, Garreta E, Richart-Ginés L, Alcazar N, Graña-Castro O, Gómez-Lopez G, Aksoy I, Muñoz-Martín M, Martinez S, Ortega S, Prieto S, Simboeck E, Camasses A, Stephan-Otto Attolini C, Fernandez AF, Sierra MI, Fraga MF, Pastor J, Fisher D, Montserrat N, Savatier P, Muñoz J, Zernicka-Goetz M, Serrano M | Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases | Nat Cell Biol | ||
| 2020 | Savatier P | An introduction to the special issue on: "Naïve pluripotency in non-rodent species: From embryos to pluripotent stem cell lines" | Exp Cell Res |
