We explore the mechanisms of self-renewal and pluripotency using embryonic stem cells from several mammalian sepcies. In particular, we explore ground state pluripotency in the rabbit and primate pre-implantation embryos.
Our goal is to create rabbit and macaque ES cells capable of colonizing the developing embryo, suitable for the generation of chimaeras.
Another aspect of our work focuses on the regulation of the cell cycle, which shows unusual characteristics in pluripotent stem cells.
| Year | Authors | Title | Journal | PubMed | |
|---|---|---|---|---|---|
| 2023 | Preeyanan Anwised, Ratree Moorawong, Worawalan Samruan, Sirilak Somredngan, Jittanun Srisutush, Chuti Laowtammathron, Irene Aksoy, Rangsun Parnpai, Pierre Savatier | An expedition in the jungle of pluripotent stem cells of non-human primates | Stem Cell Reports | ||
| 2022 | Fadlullah MZH, Neo WH, Lie-A-Ling M, Thambyrajah R, Patel R, Mevel R, Aksoy I, Do Khoa N, Savatier P, Fontenille L, Baker SM, Rattray M, Kouskoff V, Lacaud G | Murine AGM single-cell profiling identifies a continuum of hemogenic endothelium differentiation marked by ACE | Blood | ||
| 2022 | Wianny F, Dzahini K, Fifel K, Wilson CRE, Bernat A, Dolmazon V, Misery P, Lamy C, Giroud P, Cooper HM, Knoblauch K, Procyk E, Kennedy H, Savatier P, Dehay C, Vezoli J | Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: A Longitudinal Study in a Macaque Model of Parkinson's Disease | Adv Sci (Weinh) | ||
| 2022 | Wilhelm Bouchereau, Luc Jouneau, Catherine Archilla, Irène Aksoy, Anais Moulin, Nathalie Daniel, Nathalie Peynot, Sophie Calderari, Thierry Joly, Murielle Godet, Yan Jaszczyszyn, Marine Pratlong, Dany Severac, Pierre Savatier, Véronique Duranthon, Marielle Afanassieff, Nathalie Beaujean | Major transcriptomic, epigenetic and metabolic changes underlie the pluripotency continuum in rabbit preimplantation embryos | Development | ||
| 2021 | Aksoy I, Rognard C, Moulin A, Marcy G, Masfaraud E, Wianny F, Cortay V, Bellemin-Ménard A, Doerflinger N, Dirheimer M, Mayère C, Bourillot PY, Lynch C, Raineteau O, Joly T, Dehay C, Serrano M, Afanassieff M, Savatier P | Apoptosis, G1 Phase Stall, and Premature Differentiation Account for Low Chimeric Competence of Human and Rhesus Monkey Naive Pluripotent Stem Cells | Stem Cell Reports | ||
| 2021 | Savatier P | Introduction of Mouse Embryonic Fibroblasts into Early Embryos Causes Reprogramming and (Con)fusion | Cells | ||
| 2021 | Savatier P, David L, De Vos J, Yates F, Tajbakhsh S, Martinat C | Chimeric embryos and pseudo-embryos: An alternative to human embryos for research | Med Sci (Paris) | ||
| 2021 | Savatier P, Aksoy I | Interspecies systemic chimeras | Med Sci (Paris) | ||
| 2020 | Bourillot PY, Santamaria C, David L, Savatier P | GP130 signaling and the control of naïve pluripotency in humans, monkeys, and pigs | Exp Cell Res | ||
| 2020 | Savatier P | An introduction to the special issue on: "Naïve pluripotency in non-rodent species: From embryos to pluripotent stem cell lines" | Exp Cell Res |
