Discover the
SBRI member :
DR2
Research interests
Research Director at the CNRS within the Stem Cell and Brain Research Institute (SBRI), Inserm U1208, University of Lyon and Co-Founder, in 2009, of the Joint Laboratory on Neuropathogenesis along with Prof. Chonggang YUAN at East China Normal University (ECNU) in Shanghai, integrated into the Key Laboratory of Brain Functional Genomics at the ECNU in January 2014.
The main objective is the transfer of fundamental discoveries using small antibody mimetics called peptide aptamers, to potential patient benefit in the context of the StemGamE platform.
The present transfer focus: • neurodegenerative diseases - e.g. ALS (Amyotrophic Lateral Sclerosis - Maladie de Charcot) • stimulation of the immune response e.g. for adoptive cell therapy of certain cancers • enhancement of safety of the use of embryonic stem cell-derived cultures for potential therapeutic benefit.
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18 avenue du Doyen Lépine
69500 Bron Cedex France
- 04 72 91 34 43
- Brian.Rudkin@Inserm.fr
- Member of ...
- Selected publications of Brian B. Rudkin
| Year | Authors | Title | Journal | PubMed | |
|---|---|---|---|---|---|
| 2017 | Spencer A, Yu L, Guilli V, Reynaud F, Ding YD, Jullien J, Koubi D, Gauthier E, Cluet D, Rudkin BB, Falk J, Castellani V, Yuan CG | Nerve Growth Factor Signaling from Membrane Microdomains to the Nucleus: Differential Regulation by Caveolins | Int J Mol Sci | ||
| 2015 | Yu L, Reynaud F, Falk J, Spencer A, Ding YD, Baumlé V, Lu R, Castellani V, Yuan C, Rudkin BB | Highly efficient method for gene delivery into mouse dorsal root ganglia neurons. | Front Mol Neurosci | ||
| 2014 | Soldatova LN, Nadis D, King RD, Basu PS, Haddi E, Baumlé V, Saunders NJ, Marwan W, Rudkin BB | EXACT2: the semantics of biomedical protocols | BMC Bioinformatics | ||
| 2013 | Dibenedetto S, Cluet D, Stebe PN, Baumle V, Léault J, Terreux R, Bickle M, Chassey BD, Mikaelian I, Colas P, Spichty M, Zoli M, Rudkin BB | Calcineurin A versus NS5A-TP2/HD domain containing 2: a case study of site-directed low-frequency random mutagenesis for dissecting target specificity of peptide aptamers | Mol Cell Proteomics | ||
| 2012 | Yu L, Ding Y, Spencer A, Ma J, Lu R, Rudkin BB, Yuan C | Dorsal root ganglion progenitors differentiate to gamma-aminobutyric acid- and choline acetyltransferase-positive neurons | Neural Regen Res | ||
| 2011 | Lu R, Ma J, Zhang Y, Lu L, Spencer A, Cluet D, Rudkin BB, Yuan CG | Effect of Caveolin-1 on Proliferation and Survival of MCF-7 Breast | Chin J Cell Biol | ||
| 2009 | Bardou C, Borie C, Bickle M, Rudkin BB, Colas P | Peptide aptamers for small molecule drug discovery | Methods Mol Biol | ||
| 2007 | de Chassey B, Mikaelian I, Mathieu AL, Bickle M, Olivier D, Nègre D, Cosset FL, Rudkin BB, Colas P | An antiproliferative genetic screening identifies a peptide aptamer that targets calcineurin and up-regulates its activity | Mol Cell Proteomics | ||
| 2007 | Chabadel A, Bañon-Rodríguez I, Cluet D, Rudkin BB, Wehrle-Haller B, Genot E, Jurdic P, Anton IM, Saltel F | CD44 and beta3 integrin organize two functionally distinct actin-based domains in osteoclasts | Mol Biol Cell | ||
| 2007 | Abed N, Bickle M, Mari B, Schapira M, Sanjuan-España R, Robbe Sermesant K, Moncorgé O, Mouradian-Garcia S, Barbry P, Rudkin BB, Fauvarque MO, Michaud-Soret I, Colas P | A comparative analysis of perturbations caused by a gene knock-out, a dominant negative allele, and a set of peptide aptamers | Mol Cell Proteomics |