Our laboratory investigates lineage specification in the postnatal SVZ, the main germinal zone of the postnatal forebrain. We have participated to the demonstration that the SVZ is not a homogeneous germinal region, but is composed of microdomains that have different embryonic origins, distinct transcriptional signatures and are biased in generating specific neural cell types (reviewed in (Fiorelli et al 2015)).
Over the last few years, we have progressively focused on characterizing the dorsal-most domain of the postnatal SVZ (dorsal SVZ or dVSZ). This region is particularly interesting as it continues producing cells of distinct lineages, including distinct neuronal lineages. In particular, this region contains progenitors of oligodendrocytes and glutamatergic neurons, two cells type that are particularly sensitive to degeneration in a variety of pathologies.
By using a combination of molecular and imaging tools, our research addresses the following aims:
| Year | Authors | Title | Journal | PubMed | |
|---|---|---|---|---|---|
| 2019 | Marcy G, Raineteau O | Contributions of Single-Cell Approaches for Probing Heterogeneity and Dynamics of Neural Progenitors Throughout Life: Concise Review. | Stem Cells | ||
| 2018 | Zweifel S, Buquet J, Caruso L, Rousseau D, Raineteau O | "FlashMap" - A Semi-Automatic Tool for Rapid and Accurate Spatial Analysis of Marker Expression in the Subventricular Zone | Sci Rep | ||
| 2018 | Benito N, Gaborieau E, Sanz Diez A, Kosar S, Foucault L, Raineteau O, De Saint Jan D | A Pool of Postnatally Generated Interneurons Persists in an Immature Stage in the Olfactory Bulb | J Neurosci | ||
| 2018 | Gaborieau E, Hurtado-Chong A, Fernández M, Azim K, Raineteau O | A dual role for the transcription factor Sp8 in postnatal neurogenesis | Sci Rep | ||
| 2018 | Zweifel S, Marcy G, Lo Guidice Q, Li D, Heinrich C, Azim K, Raineteau O | HOPX Defines Heterogeneity of Postnatal Subventricular Zone Neural Stem Cells | Stem Cell Reports | ||
| 2018 | Donega V, Marcy G, Lo Giudice Q, Zweifel S, Angonin D, Fiorelli R, Abrous DN, Rival-Gervier S, Koehl M, Jabaudon D, Raineteau O | Transcriptional Dysregulation in Postnatal Glutamatergic Progenitors Contributes to Closure of the Cortical Neurogenic Period | Cell Rep | ||
| 2017 | Azim K, Angonin D, Marcy G, Pieropan F, Rivera A, Donega V, Cantu C, Williams G, Berninger B, Butt AM, Raineteau O | Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity | PLoS Biol | ||
| 2017 | Donega V, Raineteau O | Postnatal Neural Stem Cells: Probing their competence for cortical repair | The Neuroscientist | ||
| 2015 | Azim K, Hurtado-Chong A, Fischer B, Kumar N, Zweifel S, Taylor V, Raineteau O | Transcriptional Hallmarks of Heterogeneous Neural Stem Cell Niches of the Subventricular Zone | Stem Cells | ||
| 2015 | Fiorelli R, Fischer B, Azim K, Raineteau O | Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis | Development |
